miRNAs and lncRNAs inEchinococcusandEchinococcosis
Zhi He,Taiming Yan, Ya Yuan, Deying Yang,and Guangyou Yang
Abstract:
Echinococcosis are considered to be potentially lethal zoonotic diseases that cause serious damage to hosts. The metacestode ofEchinococcusmultilocularisandE. granulosus can result in causing the alveolar and cystic echinococcoses, respectively. Recent studies have shown that noncoding RNAs are widely expressed inEchinococcus spp. and hosts. In this review, the two main types of non-coding RNAs—long non-coding RNAs (lncRNAs) and microRNAs (miRNAs)—and the wide-scale involvement of these molecules in these parasites and their hosts were discussed. The expression pattern of miRNAs inEchinococcus spp. is species- and developmental stage-specific.Furthermore, common miRNAs were detected in threeEchinococcus spp. and their intermediate hosts. Here, we primarily focus on recent insights from transcriptome studies, the expression patterns of miRNAs and lncRNAs, and miRNA-related databases and techniques that are used to investigate miRNAs inEchinococcus and echinococcosis. This review provides new avenues for screening therapeutic and diagnostic markers.
copyright:© The Author(s).
Int. J. Mol. Sci.2020,21, 730; doi:10.3390/ijms21030730
Read Full Text: https://www.mdpi.com/1422-0067/21/3/730
